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  1. Xiao S, Chen H, Fang L, Liu C, Zhang H, Jiang Y, Hong W. Comparaison of immune resp[onses and protective efficacy of suicidal DNA vaccine and conventional DNA vaccine encoding glycoprotein C of pseudorabies virus in mice. Vaccine. 2004, 22(3-4):345-351.

  2. Jiang Y, Xiao S, Fang L, Yu X, Song Y, Niu C, Chen H. DNA vaccines co-expressing GP5 and M proteins of porcine reproductive and respiratory syndrome virus (PRRSV) display enhanced immunogenicity. Vaccine. 2006, 24(15):2869-2879.

  3. Fang L, Jiang Y, Xiao S, Niu C, Zhang H, Chen H. Enhanced immunogenicity of the modified GP5 of porcine reproductive and respiratory syndrome virus. Virus Genes. 2006, 32(1):5-11.

  4. Yu X, Xiao S, Fang L, Jiang Y, Chen H. Enhanced immunogenicity to food-and-mouth disease virus in mice vaccination with alphaviral replicon-based DNA vaccine expressing the capsid precursor polypeptide (P1). Virus Genes. 2006, 33(3):337-344.

  5. Xiong F, Xiao S, YU, Li W, Zheng H, Shang Y, Peng F, Zhao C, Zhou W, Chen H, Fang L, Zhang C. Enhanced effect of microdystrophin gene transfection by HSV-VP22 mediated intercellular protein transport. BMC Neurosci. 2007, 8:50.

  6. Xiong F, Xiao S, Peng F, Yu M, Yuan Y, Chen H, Fang L, Zhang C. HSV-VP22 enhances adenovirus-mediated microdystrophin gene transfer to skeletal muscles in dystrophin-deficient (mdx) mice. Hum Gene Ther. 2007, 18(6):490-501.

  7. Jiang Y, Fang L, Xiao S, Zhang H, Pan Y, Luo R, Li B, Chen H. Immunogenicity and protective efficacy of recombinant pseudorabies virus expressing the two major membrane-associated proteins of porcine reproductive and respiratory syndrome virus. Vaccine. 2007, 25(3):547-560.

  8. Wang S, Fang L, Fan H, Jiang Y, Pan Y, Luo R, Zhao Q, Chen H, Xiao S. Construction and immunogenicity of pseudotype baculovirus expressing GP5 and M protein of porcine reproductive and respiratory syndrome virus. Vaccine. 2007, 25(49):8220-8227.

  9. Wang D, Fang L, Li T, Luo R, Xie L, Jiang Y, Chen H, Xiao S. Molecular cloning and functional characterization of porcine IFN-β promoter stimulator 1 (IPS-1). Vet Immunol Immunopathol. 2008, 125(3-4):344-353.

  10. Fan H, Pan Y, Fang L, Wang D, Wang S, Jiang Y, Chen H, Xiao S. Construction and immunogenicity of recombinant pseudotype baculovirus expressing the capsid protein of porcine circovirus type 2 in mice. J Virol Methods. 2008, 150(1-2):21-26.

  11. Fan H, Xiao S, Tong T, Wang S, Xie L, Jiang Y, Chen H, Fang L. Immunogenicity of porcine circovirus type 2 capsid protein targeting to different subcellular compartments. Mol Immunol. 2008, 45(3):653-660.

  12. Luo R, Xiao S, Jiang Y, Jin H, Wang D, Liu M, Chen H, Fang L. Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-β production by interfering with the RIG-I signaling pathway. Mol Immunol. 2008, 45(10):2839-2846.

  13. Jiang Y, Fang L, Xiao S, Li B, Pan Y, Luo R, Chen H. A suicidal DNA vaccine co-expressing two major membrane-associated proteins of porcine reproductive and respiratory syndrome virus antigens induce protective responses. Biotechnol Lett. 2009, 31(4):509-518.

  14. Li B, Xiao S, Wang Y, Xu S, Jiang Y, Chen H, Fang L. Immunogenicity of the highly pathogenic porcine reproductive and respiratory syndrome virus GP5 protein encoded by a synthetic ORF5 gene. Vaccine. 2009, 27(13): 1957-1963.

  15. Pan Y, Zhao Q, Fang L, Luo R, Chen H, Xiao S. Efficient gene delivery into mammalian cells by recombinant baculovirus containing a hybrid cytomegalovirus promoter/Semeliki Forest virus replicon. J Gene Med. 2009, 11(11):1030-1038.

  16. Wu Q, Fang L, Wu X, Li B, Luo R, Yu Z, Jin M, Chen H, Xiao S. A pseudotype baculovirus-mediated vaccine confers protective immunity against lethal challenge with H5N1 avian influenza virus in mice and chickens. Mol Immunol. 2009, 46(11-12):2210-2217.

  17. Huang Q, Yao Q, Fan H, Xiao S, Si Y, Chen H. Development of a vaccine vector based on a subgenomic replicon of porcine reproductive and respiratory syndrome virus. J Virol Methods. 2009 Sep;160(1-2):22-8.

  18. Li B, Fang L, Xu Z, Liu S, Gao J, Jiang Y, Chen H, Xiao S. Recombination in vaccine and circulating strains of porcine reproductive and respiratory syndrome viruses. Emerg Infect Dis. 2009, 15(12):2032-2035.

  19. Wang D, Fang L, Luo R, Ye R, Fang Y, Xie L, Chen H, Xiao S. Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levels. Biochem Biophys Res Commun. 2010, 399(1):72-78.

  20. Li B, Fang L, Liu S, Zhao F, Jiang Y, Chen H, Xiao S. The genomic diversity of Chinese porcine reproductive and respiratory syndrome virus isolates from 1996 to 2009. Vet Microbiol. 2010, 10.1016/j.vetmic.1010.05.011.

  21. Jiang Y, Fang L, Luo R, Xiao S, Chen H. N-acetylpenicillamine inhibits the replication of porcine reproductive and respiratory syndrome virus in vitro.Vet Res Commun. 2010, 34(7):607-617.

  22. Liu W, Fang L, Li S, Li Q, Zhou Z, Feng Z, Luo R, Shao G, Wang L, Chen H, Xiao S. Complete genome sequence of Mycoplasma hyorhinis strain HUB-1. J. Bacteriol. 2010, 192(21): 5844-5845

  23. Pan Y, Fang L, Fan H, Luo R, Zhao Q, Chen H, Xiao S. Antitumor effects of a recombinant pseudotype baculovirus expressing Apoptin in vitro and in vivo. Int J Cancer. 2010, 126(11): 2741-2751.

  24. Xie L, Liu M, Fang L, Cai K, Wang D, Chen H, Xiao S. Molecular cloning and functional characterization of porcine stimulator of interferon genes (STING). Dev Comp Immunol. 2010, 34(8):847-854.

  25. Xie L, Fang L, Wang D, Luo R, Cai K, Chen H, Xiao S. Molecular cloning and functional characterization of porcine DNA-dependent activator of IFN-regulatory factors (DAI). Dev Comp Immunol. 2010, 34(3):293-299.

  26. Xu Z, Chang X, Xiao S, Chen H, Zhou R. Evidence for the adaptive evolution of ORF5 gene of Porcine reproductive and respiratory syndrome virus isolated in China. Acta Virol. 2010, 54(4):281-285.

  27. Wang Y, Luo R, Fang L, Wang D, Bi J, Chen H, Xiao S. Porcine reproductive and respiratory syndrome virus (PRRSV) infection activates chemokine RANTES in MARC-145 cells. Mol Immunol. 2011, 48(4): 586-591

  28. Liu W, Feng Z, Fang L, Zhou Z, Li Q, Li S, Luo R, Wang L, Chen H, Shao G, Xiao S. Complete Genome Sequence of Mycoplasma hyopneumoniae Strain 168. J. Bacteriol. 2011, 193(4): 1016-1017.

  29. Wang D, Fang L, Li P, Chen Q, Luo R, Chen H, Xiao S. Molecular cloning of the porcine RANTES promoter: functional characterization of dsDNA/dsRNA response elements in PK-15 cells. Dev Comp Immunol. 2011, 35(3): 345-351.

  30. Wang D, Fang L, Zhao F, Luo R, Chen H, Xiao S. Molecular cloning, expression and antiviral activity of porcine interleukin-29 (poIL-29). Dev Comp Immunol. 2011, 35(3): 378-784.

  31. Zeng S, Wang D, Fang L, Ma J, Song T, Zhang R, Chen H, Xiao S. Complete coding sequences and phylogenetic analysis of porcine bocavirus (PBoV). J Gen Virol. 2011, 92(4): 784-788.

  32. Luo R, Fang L, Jiang Y, Jin H, Wang Y, Wang D, Chen H, Xiao S. Activation of NF-κB by necleocapsid protein of the Porcine reproductive and respiratory syndrome virus (PRRSV). Virus Genes. 2011, 42(1):76-81.

  33. Liu M, Tan C, Fang L, Xiao S, Chen H. Microarray analyses of THP-1 cells infected with Streptococcus suis serotype 2. Vet Microbiol. 2011, 150(1-2): 753-758.

  34. Wang D, Fang L, Li P, Sun L, Fan J, Zhang Q, Luo R, Liu X, Li K, Chen H, Chen Z, Xiao S. The leader proteinase of foot-and-mouth disease virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase. J. Virol. 2011, 85(8): 3758-3766.

  35. Huang H, Xiao S, Qin J, Jiang Y, Yang S, Li T, Gao Y, Li Z, Li T, Su X, Ruan Y, Xu F, Wang H, Chen H, Xia X. Construction and immunogenicity of a recombinant pseudotype baculovirus expressing the glycoprotein of rabies virus in mice. Arch Virol. 2011, 156(5):753-758.

  36. Xu Z, Xiao S, Xu P, Xie T, Cao L, Wang D, Luo R, Zhong Y, Chen H, Fang L. miR-365, a novel negative regulator of IL-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB. J Biol Chem. 2011, 286(24):21401-21412.

  37. Wang D, Fang L, Bi J, Chen Q, Cao L, Luo R, Chen H, Xiao S. Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription in PK-15 cells. Virus Genes. 2011,42(3): 388-393

  38. Liu M, Fang L, Tan C, Long T, Chen H, Xiao S. Understanding Streptococcus suis serotype 2 infection in pigs through a transcriptional approach. BMC Genomics. 2011, 12(1):253

  39. Li B, Fang L, Guo X, Gao J, Song T, Bi J, He K, Chen H, Xiao S. Epidemiology and evolutionary characteristics of the porcine reproductive and respiratory syndrome virus in China between 2006 and 2010. J Clin Microbiol. 2011, 49(9): 3175-3183.

  40. Wang D, Fang L, Liu L, Zhong H, Chen Q, Luo R, Liu X, Zhang Z, Chen H, Xiao S. Foot-and-mouth disease virus (FMDV) leader proteinase negatively regulates the porcine interferon-λ1 pathway. Mol Immunol. 2011, 49(1-2): 407-412.

  41. Fang Y, Fang L, Wang Y, Lei Y, Luo R, Wang D, Chen H, Xiao S. Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-κB activation. Virol J. 2012, 9: 83.

  42. Song T, Fang L, Zeng S, Li B, Chen H, Xiao S. Complete genome sequence of porcine reproductive and respiratory syndrome virus isolated from piglet stool sample. J Virol. 2012, 86(7):4040-4041.

  43. Liu W, Fang L, Li M, Li S, Guo S, Luo R, Feng Z, Li B, Zhou Z, Shao G, Chen H, Xiao S. Comparative genomics of Mycoplasma: analysis of conserved essential genes and diversity of the pan-genome. PLoS One. 2012, 7(4):e35698.

  44. Cao J, Li B, Fang L, Chen H, Xiao S. Pathogenesis on nonsuppurative encephalitis caused by highly pathogenic porcine reproductive and respiratory syndrome virus). J Vet Diagn Invest. 2012, 24(4):767-771.

  45. Lin Y, Xiao S, Zeng Y, Song T, Zeng S, Chen H, Fang L. Complete Genome Sequence of Porcine Kobuvirus Strain WUH1. J Virol. 2012, 86(12):7010.

  46. Wang D, Fang L, Li K, Zhong H, Chen H, Xiao S. Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling. J Virol. 2012, 86(17): 9311-9322.

  47. Bi J, Zeng S, Xiao S, Chen H, Fang L. Complete genome sequence of porcine epidemic diarrhea virus strain AJ1102 isolated from a suckling piglet with acute diarrhea in China. J Virol. 2012, 86(19): 10910-10911.

  48. Wu Q, Xu F, Fang L, Xu J, Li B, Jiang Y, Chen H, Xiao S. Enhanced immunogenicity induced by an alphavirus replicon-based pseudotyped baculovirus vaccine against porcine reproductive and respiratory syndrome virus. J Virol Methods. 2013, 187(2):251-258.

  49. Song S, Bi J, Wang D, Fang L, Zhang L, Li F, Chen H, Xiao S. Porcine reproductive and respiratory syndrome virus infection activates IL-10 production through NF-κB and p38 MAPK pathways in porcine alveolar macrophages. Dev Comp Immunol. 2013, 39(3):265-272.

  50. Wang D, Cao L, Xu Z, Fang L, Zhong Y, Chen Q, Luo R, Chen H, Li K, Xiao S. miR-125b reduces porcine reproductive and respiratory syndrome virus replication by negatively regulating the NF-κB pathway. PLoS One. 2013, 8(2): e55838

  51. Liu W, Xiao S, Li M, Guo S, Li S, Luo R, Feng Z, Li B, Zhou Z, Shao G, Chen H, Fang L. Comparative genomic analyses of Mycoplasma hyopneumoniae pathogenic 168 strain and its high-passaged attenuated strain. BMC Genomics. 2013,14(1): 80

  52. Zhong H, Wang D, Fang L, Zhang H, Luo R, Shang M, Ouyang C, Ouyang H, Chen H, Xiao S. Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling. PLoS One. 2013, 8(11): e80976.

  53. Chen Q, Liu Q, Liu D, Wang Dg, Chen H, Xiao S, Fang L. Molecular cloning, functional characterization and antiviral activity of porcine DDX3X. Biochem Biophys Res Commun. 2014, 443(4):1169–1175.

  54. Luo R, Fang L, Jin H, Wang D, An K, Xu N, Chen H, Xiao S. Label-free quantitative phosphoproteomic analysis reveals differentially regulated proteins and pathway in PRRSV infected pulmonary alveolar macrophages. J Proteome Res. 2014, 13 (3): 1270–1280.

  55. Jing H, Fang L, Wang D, Ding Z, Luo R, Chen H, Xiao S. Porcine reproductive and respiratory syndrome virus infection activates NOD2-RIP2 signal pathway in MARC-145 cells. Virology. 2014, 458-459: 162-171.

  56. Bi J, Song S, Fang L, Wang D, Jing H, Gao L, Cai Y, Luo R, Chen H, Xiao S. Porcine reproductive and respiratory syndrome virus induces IL-1ß production depending on TLR4/MyD88 pathway and NLRP3 inflammasome in primary porcine alveolar macrophages. Mediators Inflamm. 2014, vol.2014, Article ID 403515

  57. Ding Z, Fang L, Jing H, Zeng S, Wang D, Liu L, Zhang H, Luo R, Chen H, Xiao S. Porcine epidemic diarrhea virus (PEDV) nucleocapsid protein antagonizes IFN-β production by sequestering the interaction between IRF3 and TBK1. J Virol. 2014, 88(16): 8936-8945.

  58. Wang D, Fang L, Wei D, Zhang H, Luo R, Chen H, Li K, Xiao S. Hepatitis A virus 3C protease cleaves NEMO to impair induction of beta interferon. J Virol. 2014, 88(17): 10252-10258.

  59. Duan E, Wang D, Luo R, Luo J, Gao L, Chen H, Fang L, Xiao S. Porcine reproductive and respiratory syndrome virus infection triggers HMGB1 release to promote inflammatory cytokine production. Virology. 2014, 468-470:1-9.

  60. Zhu X, Wang D, Zhang H, Zhou Y, Luo R, Chen H, Xiao S, Fang L. Molecular cloning and functional characterization of porcine DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41). Dev Comp Immunol. 2014, 47(2):191-196.

  61. An K, Fang L, Luo R, Wang D, Xie L, Yang J, Chen H, Xiao S. Quantitative proteomic analysis reveals that transmissible gastroenteritis virus (TGEV) activates JAK-STAT1 signaling pathway. J Proteome Res. 2014, 13(12):5376-5390.

  62. Zeng S, Zhang H, Ding Z, Luo R, An K, Liu L, Bi J, Chen H, Xiao S, Fang L. Proteome analysis of porcine epidemic diarrhea virus (PEDV)-infected Vero cells. Proteomics. 2015, 15(11):1819-1828.

  63. Zhang H, Ouyang H, Wang D, Shi J, Ouyang C, Chen H, Xiao S, Fang L. Mycobacterium tuberculosis Rv2185c contributes to Nuclear factor-κB activation. Mol Immunol. 2015, 66(2):147-153.

  64. Zhang H, Wang D, Zhong H, Luo R, Shang M, Liu D, Chen H, Fang L, Xiao S. Ubiquitin-specific protease 15 negatively regulates virus-induced type I interferon signaling via catalytically-dependent and -independent mechanisms. Sci Rep. 2015, 5:11220.

  65. Duan E, Wang D, Fang L, Ma J, Luo J, Chen H, Li K, Xiao S. Suppression of porcine reproductive and respiratory syndrome virus proliferation by glycyrrhizin. Antiviral Res. 2015, 120:122-125.

  66. Dong N, Fang L, Zeng S, Sun Q, Chen H, Xiao S. Porcine Deltacoronavirus in Mainland China. Emerg Infect Dis. 2015, 21(12):2254-2255.

  67. Zhang R, Fang L, Wang D, Cai K, Zhang H, Xie L, Li Y, Chen H, Xiao S. Porcine bocavirus NP1 negatively regulates interferon signaling pathway by targeting the DNA-binding domain of IRF9. Virology. 2015, 485:414-421.

  68. Wang D, Fan J, Fang L, Luo R, Ouyang H, Ouyang C, Zhang H, Chen H, Li K, Xiao S. The Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus Inhibits NF-<kappa>B Signaling by means of its Deubiquitinating Activity. Mol Immunol. 2015, 68(2): 357-366.

  69. Du T, Cai K, Han H, Fang L, Liang J, Xiao S. Probing the interactions of CdTe quantum dots with pseudorabies virus. Sci Rep. 2015, 5: 16403.

  70. Wang D, Fang L, Shi Y, Zhang H, Gao L, Peng G, Chen H, Li K, Xiao S. Porcine epidemic diarrhoea virus 3C-like protease regulates its interferon antagonism by cleaving NEMO. J Virol. 2016, 90(4): 2090-2101.

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